Oral Administration of an Ethanolic Extract from Cynara cardunculus var. scolymus: Its Effects on Serum Enzymes in Animals and Assessment of Its α-glucosidase and α-amylase Inhibitory Activity
10.52845/CMRO/2025/8-12-5
Abstract
The positive attributes of the edible Cynara cardunculus L. subsp. scolymus, commonly referred to as globe artichoke, have long been known due to the amount of bioactive chemicals found in it including inulin and polyphenols. Artichokes, which were washed under tap water, were picked manually and consumed as edibles and commercially viable. They were then frozen at -20 o C and then freeze dried after the removal of stems and outer bracts. Removal of the outerbracts had to be done thrice. Cynaran and caffeic acid were the metabolized compounds. Octyl alpha-D-glucopyranoside, Salvadoraside, 1, 4-o-Caffeoyl quinic acid, 5-Feruloylquinic acid, Apigenin 7-O-rut, and several others. The comparative values with respect to 2 alpha-amylase were (39.00±2.09, 71.81±5.83, 85.00±6.07, and 32.93±2.01) in regard to the type of extract (ethanol fraction, ethyl acetate fraction, water fraction and acarbose as standard). The 6-glucosidase inhibitory power was determined to be (61.09±4.00, 41.00±2.98, 30.05±1.99, and 20.00±0.67), respectively. Researchers studied the effect of the SGPT, SGOT, and ALP in the blood of rats by oral administration of Cynara cardunculus var. scolymus extract in a controlled environment. The outcomes of these experiments that involved ethyl acetate extract of Cynara cardunculus var. scolymus, Di-(2-ethylhexyl) phthalate, and Control (0.5 ml/kg corn oil) were (90.00±4.86, 103.54±5.67, and 37.00±2.98), respectively.
Keywords
- Cynara cardunculus var. scolymus
- Serum Enzymes
- Animals
- α-glucosidase
- α-amylase
How to Cite
Rana F. M. Al-Dulaimi, Ikhlas Fayhan Musa Al-Dulaimi . (2025). Oral Administration of an Ethanolic Extract from Cynara cardunculus var. scolymus: Its Effects on Serum Enzymes in Animals and Assessment of Its α-glucosidase and α-amylase Inhibitory Activity. Journal of Current Medical Research and Opinion , Vol. 8 No. 12 (2025) , 4557-4568 . https://doi.org/10.52845/CMRO/2025/8-12-5