Investigation of the Bioactive Components of Ginger rhizome (Zingiber officinale) and Its Anti-Inflammatory Activity as Assessed by Solvent Fractions
10.52845/CMRO/2025/8-12-3
Abstract
A popular spice known as ginger, or Zingiber officinale, has chemicals like shogaols and gingerols that have anti-inflammatory effects. These compounds lessen inflammation, discomfort, and swelling by blocking certain pathways like NF-κB and reducing inflammatory mediators like prostaglandins and leukotrienes. More large-scale trials are needed to confirm ginger's potential in controlling inflammatory disorders, but it shows promise in gastrointestinal difficulties and arthritis, and it has less adverse effects than some NSAIDs. With precise weighing, one gram of sample was mixed with one hundred milliliters of solvent. In the absence of a different instruction, it was centrifuged at 4000 rpm for 20 minutes after being shaken for 3 hours at room temperature. Whatman No. 1 filter paper was then used for the filtration process. New extracts were utilized in every trial. Alpha-Phellandrene, α-pinene, α-Terpineol, Gingerol, beta-Bisabolene, β-Elemene, 6-Shogaol, and Zingherone were the bioactive components of Zingiber officinale. The effects of Zingiber officinale ethyl acetate extract on the serum enzymes SGPT, SGOT, and ALP were studied in laboratory rats using in vitro experimental testing. The results for Zingiber officinale ethyl acetate extract were 93.00±4.40, 70.95±3.86, and 25.00±1.92, respectively. In contrast, the results for Di-(2- ethylhexyl) phthalate were 149.07±6.28, 114.00±4.37, and 35.06±2.08, respectively. The results for the Control group, which consisted of 0.5 ml/kg of corn oil, were 71.00±3.95, 62.04±2.09, and 16.05±1.08.
Keywords
- Anti-inflammatory
- Zingiber officinale
- Bioactive components
How to Cite
Rabab J.H. Al Hasseny, Abbas K. Al-Mansoori, Safa Fadhil Rasool, Toqa M.A. Mhayyal . (2025). Investigation of the Bioactive Components of Ginger rhizome (Zingiber officinale) and Its Anti-Inflammatory Activity as Assessed by Solvent Fractions. Journal of Current Medical Research and Opinion , Vol. 8 No. 12 (2025) , 4537-4545 . https://doi.org/10.52845/CMRO/2025/8-12-3