01
Abstract
Background: Vitamin D has been found to have conflicting effects in trials and cohorts for chronic low-grade inflammation, which is one of the elements involved in the pathogenesis of type 2 diabetic mellitus (T2DM). Adults were the patients who visited the Akad laboratory in British Columbia, USA, with type 2 diabetes mellitus. The aim of this study was to measure and correlate their serum vitamin D3 and inflammatory markers such as C-reactive protein (CRP) and haemoglobin A1c (HbA1c). In a cross-sectional study of 50 adults with type 2 diabetes mellitus (30-69 years; 23 males, 27 females), serum vitamin D3, HbA1c and CRP levels were measured after recording age, weight and height. Association was assessed using multiple linear regression, one-way ANOVA and Pearson / Spearman correlations. The end product was C-reactive protein (CRP) and the predictors were age, Vitamin D3 and BMI. The level of significance (α) was used at 0.05.
Results: Seventy-two point of participants had vitamin D3 deficiency (<20 ng/mL). Baseline mean ± SD values were: vitamin D3, 18.7 ± 9.9 ng/mL; HbA1c, 8.25 ± 2.11%; CRP, 11.8 ± 8.0 mg/LNo significant correlation between vitamin D3 and CRP (Pearson r =. 76; Spearman ρ = −0.06, p =. The association of HbA1c and CRP was also not significant but in a direction expected (r = 0.22, p =. 12; ρ = 0.27, p =. 056). The multiple regression model explained almost none of the variance in CRP (adjusted R² = −0.06, F = 0.06, p = … 98). CRP was significantly higher in females as compared to males (14.1 ± 9.0 versus 9.2 ± 5.7mg/L; t =−2.34, p= <. 024; Mann-Whitney p =. 023; Cohen's d = 0.64) and a non-significant tendency for higher blood levels of vitamin D3 (21.1 ± 11.7 vs 16.0 ± 6.5 ng/mL p =. 059. 077 across tests).
Conclusions: This small, cross-sectional study of Iraqi type 2 diabetics did not reveal any association between vitamin D3 and CRP and it also failed to confirm the inverse association between vitamin D and CRP as reported previously. Nevertheless, when looking at corrected CRP levels, it was found that vitamin D3 deficiency was quite common in both sexes and was unrelated to body mass index; men had much lower CRP levels than women. The results show that the vitamin D CRP association varies significantly at the study level, which is in line with meta-analysis findings. It is not recommended to use vitamin D status determination to inform inflammation management in the treatment of type 2 diabetes until larger, longitudinal cohort studies are performed.
10.52845/