Journal of Current Medical Research and Opinion <p><em><strong>Journal of Current Medical Research and Opinion</strong>&nbsp;</em>is a&nbsp; peer-reviewed, international journal for the rapid publication of original research on new and existing drugs and therapies,&nbsp; and post-marketing investigations. Equivalence, safety and efficacy/effectiveness studies are especially encouraged.&nbsp;</p> <p>The aim of&nbsp;<em><strong>Journal of Current Medical Research and Opinion</strong>&nbsp;</em>is to provide ethical, unbiased and rapid publication of quality content that is validated by rigorous peer review. Journal aim is to serve the information needs of the clinical medicine community, to help translate medical advances into patient care and be a leader in transparency/disclosure by facilitating a collaborative and honest approach to publication.</p> en-US (Praveen Kottathveetil) (Gaurav Daga) Thu, 07 Jun 2018 11:35:29 +0000 OJS 60 Prosthetic Mesh Repair in Obstructed Inguinal Hernia: A Research Analysis <p><strong>Introduction:</strong> Inguinal hernia is a commonly encountered urgent condition in surgical clinics. An abdominal wall hernia is a protrusion of the abdominal tissues or organs through&nbsp;a weakness in the muscular structure of the wall of the abdomen. Inguinal and femoral hernias are usually classified together as groin hernias.</p> <p><strong>Objective of the study:</strong> The main objective of the study was to compare the outcomes of different surgical techniques performed for inguinal hernia, and to evaluate the effect of&nbsp;prosthetic mesh repair in obstructed inguinal hernia.</p> <p><strong>Methodology of the study:</strong> This retrospective study was performed with 70 patients who had been admitted to our hospital’s emergency department between 2016 and 2017 to undergo surgery for a diagnosis of obstructed inguinal hernia.</p> <p><strong>Results:</strong> The patients were divided into two groups based on the applied surgical technique. In Group 1, it was observed that eight of the patients had wound infections, while two had hematomas, four had seromas, and one had relapse. In Group 2, one of the patients had a wound infection, while three had hematomas, one had seroma, and none had relapses. In Group 3, it was observed that one of the patients had wound infections, while one had a hematoma,</p> <p>&nbsp;</p> <p>one patient had seroma, and none had relapses. In Group 4, seven of the patients had wound infections, while one had a hematoma, three had seromas, and one had a relapse. <strong>Conclusion:</strong> There were no significant differences between the two groups with respect to wound infection, seroma, hematoma, or relapse (p&gt;0.05). In urgent groin hernia repair surgeries, polypropylene mesh can be safely used even in the patients undergoing bowel resection.</p> Ali Gohar Khan, Sadam Zia, Syed Khizar Naim,Abdul aziz laghari, Saba ashraf, Arooj Fatima ##submission.copyrightStatement## Fri, 01 Jun 2018 00:00:00 +0000 The Etiology and Treatment of Bronchiolitis In Children (A Review) <p>Respiratory syncytial virus (RSV) is the main cause of bronchiolitis in infants, and it is commonly the main cause of epidemics. The main cause of bronchiolitis is generally viral, including RSV, human metapneumovirus, influenza virus, human parainfluenza viruses, adenoviruses, and rhinovirus. From among the bacterial causes, pertussis has been introduced as the one making bronchiolitis symptoms. As the age increases, the prevalence rate and severity of diseases arising from RSV decreases. This virus brings about 90,000 hospitalization cases and 4500 deaths in the United States. This virus has been observed in at least 20% of the children hospitalized. The treatment of bronchiolitis is a supportive one, and it includes monitoring, fever control, proper hydration, upper airway suctioning, and oxygen prescription. The main treatment of bronchiolitis is oxygen prescription; patients feeling worse tend to be hypoxic. The oxygen saturation percentage needs to be at the level of 92% or higher. For this purpose, the prescription of lukewarm and wet oxygen (30% to 40%) through mask or nasogastric tube is sufficient. Bronchiolitis complications include apnea, dehydration, electrolyte disorders (usually hyponatremia), added bacterial infection, myocardial dysfunction, Myocarditis, and respiratory failure. Most of the children hospitalized in the hospital will recover significantly only through a supportive treatment within 2-5 days. After the recovery, wheezing or coughing lasted for several weeks or months in less than 20% of the patients. Older children and adults produce an antibody against RSV. However, the immunity is not complete and reinfection can occur at any age.</p> Magid Reza Akbarizadeh ##submission.copyrightStatement## Fri, 01 Jun 2018 00:00:00 +0000 Metabolic syndrome (A Review) <h2><strong>Since the 1960s, there has been a correlation between high levels of serum triglycerides, obesity, insulin resistance, glucose intolerance, hypertension and cardiovascular disease (CAD). In 1988, Reaven introduced the concept of metabolic syndrome (syndrome x) to aggregate these risk factors for cardiovascular disease. Since insulin resistance may be the cause of such a combination of risk factors involved in the onset of type-2 diabetes or cardiovascular disease, Insulin Resistance Syndrome has, also, been introduced for this disorder. The first international definition for this syndrome was presented in 1998 by the World Health Organization. In 2002, Panel 3 of Adult Treatment in the National Cholesterol Education Program in America (NCEP / ATPIII) considered the presence of three of five cases (Hypertension, Central Obesity, Hip More triglyceridemi, and hyperglycemia, reduced Castrol HDL) sufficient for the diagnosis of metabolic syndrome. Insulin resistance is the most accepted hypothesis in describing the pathophysiology of the metabolic syndrome and is caused by an unknown insulin-induced defect. Insulin resistance is induced by hyperinsulinemia after food, followed by a patient with fasting hyperinsulinaemia and ultimately hyperglycemia. The first and foremost factor in creating insulin resistance is the excessive amount of fatty acids in circulation. Free fatty acids linked to plasma albumin are mainly released due to the activity of hormone-sensitive lipase activity from lipid triglyceride stores. Fatty acids are also produced by lipoprotein lipase due to lipopolysate of lipid triglycerides-rich lipoprotein proteins. It has anti-lipolysis and also stimulates the activity of lipoprotein lipase in the tissue.</strong></h2> Zohreh Mahmoodi ##submission.copyrightStatement## Fri, 01 Jun 2018 00:00:00 +0000 Respiratory distress syndrome in infants (A Review) <p><strong>Abstract:</strong></p> <p>Preterm labor is the main cause of infant mortality in advanced countries; babies born preterm are at higher risk for short-term and long-term complications, including physical disability and mental development. Due to severe neonatal complications often followed, preterm labor is a very serious problem. Some of these complications include respiratory distress syndrome, intracranial hemorrhage, sepsis, and necrotizing colitis , many of which might lead to the death of the infant. One of the major problems of preterm infants is the lack of adequate lung function and, consequently, respiratory distress, known as "Neonatal Respiratory Distress Syndrome" . The most common reason for admission of preterm and term infants in hospitals is respiratory disease for special care. Respiratory distress syndrome is more prevalent in preterm infants, and its incidence is related to birth weight and intrauterine age. To paint a general picture, it is prevalent in infants of diabetic mothers, gestational age under 37 weeks, multiple pregnancy, the implementation of caesarean section, accelerated delivery and cold stress. It is most common in newborns. The main cause of respiratory distress syndrome in newborns is the lack of surfactant in the baby's lung. The main components of surfactant are lecithin (disalmotyl phosphatidyl choline), phosphatidyl glycerol, apoproteins (SP-A, B, C, D) and glycerol .With increased uterine age, more phospholipid is produced and stored in type 2 alveolar cells. These agents are released into the alveoli and reduce the surface tension and help prevent collapse of the small airway at the tail end and help rehabilitate the lung after exhalation; however, he amount that is produced and secreted may not be adequate to meet</p> <p>&nbsp;</p> <p>the premature baby's demand. At 20 weeks of pregnancy, surfactant is present with high concentrations in the lung tissue of the fetus, but it doesn't reaches the level of the lung alveoli; it appears in amniotic fluid between 28 and 32 weeks</p> Anis Mohammad A, Osman Khan ##submission.copyrightStatement## Fri, 01 Jun 2018 00:00:00 +0000 Three Species of Main Bacteria in Treatment of Cancer <p>Cancer is characterized by uncontrolled and invasive growth of cells. These cells may spread to other parts of the body, and this is called metastasis. Bacterial treatment is a new idea in world. In this letter three species of main bacteria in treatment of cancer will introduce.</p> Seyed Hossein Shahcheraghi ##submission.copyrightStatement## Fri, 01 Jun 2018 00:00:00 +0000