Metabolic syndrome (A Review)

  • Zohreh Mahmoodi Department of Cardiology, Zabol University of Medical Sciences, Zabol, Iran

Abstract

Since the 1960s, there has been a correlation between high levels of serum triglycerides, obesity, insulin resistance, glucose intolerance, hypertension and cardiovascular disease (CAD). In 1988, Reaven introduced the concept of metabolic syndrome (syndrome x) to aggregate these risk factors for cardiovascular disease. Since insulin resistance may be the cause of such a combination of risk factors involved in the onset of type-2 diabetes or cardiovascular disease, Insulin Resistance Syndrome has, also, been introduced for this disorder. The first international definition for this syndrome was presented in 1998 by the World Health Organization. In 2002, Panel 3 of Adult Treatment in the National Cholesterol Education Program in America (NCEP / ATPIII) considered the presence of three of five cases (Hypertension, Central Obesity, Hip More triglyceridemi, and hyperglycemia, reduced Castrol HDL) sufficient for the diagnosis of metabolic syndrome. Insulin resistance is the most accepted hypothesis in describing the pathophysiology of the metabolic syndrome and is caused by an unknown insulin-induced defect. Insulin resistance is induced by hyperinsulinemia after food, followed by a patient with fasting hyperinsulinaemia and ultimately hyperglycemia. The first and foremost factor in creating insulin resistance is the excessive amount of fatty acids in circulation. Free fatty acids linked to plasma albumin are mainly released due to the activity of hormone-sensitive lipase activity from lipid triglyceride stores. Fatty acids are also produced by lipoprotein lipase due to lipopolysate of lipid triglycerides-rich lipoprotein proteins. It has anti-lipolysis and also stimulates the activity of lipoprotein lipase in the tissue.
Published
2018-06-01
How to Cite
Mahmoodi, Z. (2018). Metabolic syndrome (A Review). Journal of Current Medical Research and Opinion, 1(01), 9-12. Retrieved from http://manuscriptcentral.info/index.php/cmro/article/view/4
Section
Articles